DeepNitro: Prediction of Protein Nitration and Nitrosylation Sites by Deep Learning.

ABSTRACT: Protein nitration and nitrosylation are essential post-translational modifications (PTMs) involved in many fundamental cellular processes. Recent studies have revealed that excessive levels of nitration and nitrosylation in some critical proteins are linked to numerous chronic diseases. Therefore, the identification of substrates that undergo such modifications in a site-specific manner is an important research topic in the community and will provide candidates for targeted therapy. In this study, we aimed to develop a computational tool for predicting nitration and nitrosylation sites in proteins. We first constructed four types of encoding features, including positional amino acid distributions, sequence contextual dependencies, physicochemical properties, and position-specific scoring f

SUBMITTER: Xie Y 

PROVIDER: S-EPMC6205083 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature