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ESM-CT: a precise method for localization of DBS electrodes in CT images.

ABSTRACT: BACKGROUND:Deep brain stimulation (DBS) of the subthalamic nucleus produces variable effects in Parkinson disease. Variation may result from different electrode positions relative to target. Thus, precise electrode localization is crucial when investigating DBS effects. NEW METHOD:We developed a semi-automated method, Electrode Shaft Modeling in CT images (ESM-CT) to reconstruct DBS lead trajectories and contact locations. We evaluated methodological sensitivity to operator-dependent steps, robustness to image resampling, and test-retest replicability. ESM-CT was applied in 56 patients to study electrode position change (and relation to time between scans, postoperative subdural air volume, and head tilt during acquisition) between images acquired immediately post-implantation (DBS-CT) and months later (DEL-CT). RESULTS:Electrode tip localization was robust to image resampling and replicable to within ? 0.2?mm on test-retest comparisons. Systematic electrode displacement occurred rostral-ventral-lateral between DBS-CT and DEL-CT scans. Head angle was a major explanatory factor (p?

SUBMITTER: Milchenko M

PROVIDER: S-EPMC6205293 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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ESM-CT: a precise method for localization of DBS electrodes in CT images.

Milchenko Mikhail M Snyder Abraham Z AZ Campbell Meghan C MC Dowling Joshua L JL Rich Keith M KM Brier Lindsey M LM Perlmutter Joel S JS Norris Scott A SA

Journal of neuroscience methods 20180907

<h4>Background</h4>Deep brain stimulation (DBS) of the subthalamic nucleus produces variable effects in Parkinson disease. Variation may result from different electrode positions relative to target. Thus, precise electrode localization is crucial when investigating DBS effects.<h4>New method</h4>We developed a semi-automated method, Electrode Shaft Modeling in CT images (ESM-CT) to reconstruct DBS lead trajectories and contact locations. We evaluated methodological sensitivity to operator-depend ...[more]

PMID: 30201271

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ESM-CT: a precise method for localization of DBS electrodes in CT images.

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ESM-CT: a precise method for localization of DBS electrodes in CT images.

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