Ontology highlight
ABSTRACT:
SUBMITTER: Abraham DM
PROVIDER: S-EPMC6205385 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Abraham Dennis M DM Lee Teresa E TE Watson Lewis J LJ Mao Lan L Chandok Gurangad G Wang Hong-Gang HG Frangakis Stephan S Pitt Geoffrey S GS Shah Svati H SH Wolf Matthew J MJ Rockman Howard A HA
The Journal of clinical investigation 20181002 11
Cardiac two-pore domain potassium channels (K2P) exist in organisms from Drosophila to humans; however, their role in cardiac function is not known. We identified a K2P gene, CG8713 (sandman), in a Drosophila genetic screen and show that sandman is critical to cardiac function. Mice lacking an ortholog of sandman, TWIK-related potassium channel (TREK-1, also known Kcnk2), exhibit exaggerated pressure overload-induced concentric hypertrophy and alterations in fetal gene expression, yet retain pre ...[more]