Ontology highlight
ABSTRACT:
SUBMITTER: Smith CC
PROVIDER: S-EPMC6205406 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Smith Christof C CC Beckermann Kathryn E KE Bortone Dante S DS De Cubas Aguirre A AA Bixby Lisa M LM Lee Samuel J SJ Panda Anshuman A Ganesan Shridar S Bhanot Gyan G Wallen Eric M EM Milowsky Matthew I MI Kim William Y WY Rathmell W Kimryn WK Swanstrom Ronald R Parker Joel S JS Serody Jonathan S JS Selitsky Sara R SR Vincent Benjamin G BG
The Journal of clinical investigation 20181002 11
Human endogenous retroviruses (hERVs) are remnants of exogenous retroviruses that have integrated into the genome throughout evolution. We developed a computational workflow, hervQuant, which identified more than 3,000 transcriptionally active hERVs within The Cancer Genome Atlas (TCGA) pan-cancer RNA-Seq database. hERV expression was associated with clinical prognosis in several tumor types, most significantly clear cell renal cell carcinoma (ccRCC). We explored two mechanisms by which hERV exp ...[more]