Ontology highlight
ABSTRACT:
SUBMITTER: Guseman AJ
PROVIDER: S-EPMC6205421 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Guseman Alex J AJ Perez Goncalves Gerardo M GM Speer Shannon L SL Young Gregory B GB Pielak Gary J GJ
Proceedings of the National Academy of Sciences of the United States of America 20181009 43
Protein-protein interactions are usually studied in dilute buffered solutions with macromolecule concentrations of <10 g/L. In cells, however, the macromolecule concentration can exceed 300 g/L, resulting in nonspecific interactions between macromolecules. These interactions can be divided into hard-core steric repulsions and "soft" chemical interactions. Here, we test a hypothesis from scaled particle theory; the influence of hard-core repulsions on a protein dimer depends on its shape. We test ...[more]