Dataset Information

EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study.

ABSTRACT:

Background and aims

Portal hypertension is a serious adverse event of liver cirrhosis. Recently, we developed a simple novel technique for EUS-guided portal pressure gradient (PPG) measurement (PPGM). Our animal studies showed excellent correlation between EUS-PPGM and interventional radiology-acquired PPGM. In this video we demonstrate the results of the first human pilot study of EUS-PPGM in patients with liver disease.

Methods

EUS-PPGM was performed by experienced endosonographers using a linear echoendoscope, a 25-gauge FNA needle, and a novel compact manometer. The portal vein and hepatic vein (or inferior vena cava) were targeted by use of a transgastric or transduodenal approach. Feasibility was defined as successful PPGM in each patient. Safety was based on adverse events captured in a postprocedural interview.

Results

Twenty-eight patients underwent EUS-PPGM with 100% technical success and no adverse events. PPG ranged from 1.5 to 19 mm Hg and had excellent correlation with clinical parameters of portal hypertension, including the presence of varices (P = .0002), PH gastropathy (P = .007), and thrombocytopenia (P = .036).

Conclusion

This novel technique of EUS-PPGM using a 25-gauge needle and compact manometer is feasible and appears safe. Given the availability of EUS and the simplicity of the manometry setup, EUS-guided PPG may represent a promising breakthrough for procuring indispensable information in the management of patients with liver disease.

SUBMITTER: Samarasena JB

PROVIDER: S-EPMC6205538 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study.

Samarasena Jason B JB Huang Jason Y JY Tsujino Takeshi T Thieu Daniel D Yu Allen A Hu Ke-Qin KQ Lee John J Chang Kenneth J KJ

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy 20181025 11

<h4>Background and aims</h4>Portal hypertension is a serious adverse event of liver cirrhosis. Recently, we developed a simple novel technique for EUS-guided portal pressure gradient (PPG) measurement (PPGM). Our animal studies showed excellent correlation between EUS-PPGM and interventional radiology-acquired PPGM. In this video we demonstrate the results of the first human pilot study of EUS-PPGM in patients with liver disease.<h4>Methods</h4>EUS-PPGM was performed by experienced endosonograph ...[more]

PMID: 30402586

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Dataset Information

EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study.

Background and aims

Methods

Results

Conclusion

Publications

EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study.

Similar Datasets

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