Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.
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ABSTRACT:
SUBMITTER: Greenhalgh AD
PROVIDER: S-EPMC6205650 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.
Greenhalgh Andrew D AD Zarruk Juan G JG Healy Luke M LM Baskar Jesudasan Sam J SJ Jhelum Priya P Salmon Christopher K CK Formanek Albert A Russo Matthew V MV Antel Jack P JP McGavern Dorian B DB McColl Barry W BW David Samuel S
PLoS biology 20181017 10
Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macrophages. In the context of spinal cord injury (SCI), ...[more]
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