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MCL-1 inhibition in cancer treatment.

ABSTRACT: Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human primary and drug-resistant cancer cells makes it an attractive cancer therapeutic target. Significant progress has been made in the development of small-molecule MCL-1 inhibitors in recent years, and three MCL-1 selective inhibitors have advanced to clinical trials. This review briefly discusses recent advances in the development of small molecules targeting MCL-1 for cancer therapy.

SUBMITTER: Xiang W

PROVIDER: S-EPMC6205821 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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MCL-1 inhibition in cancer treatment.

Xiang Weiguo W Yang Chao-Yie CY Bai Longchuan L

OncoTargets and therapy 20181023

Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human primary and drug-resistant cancer cells makes it an attractive cancer therapeutic target. Significant progress has been made in the development of small-molecule MCL-1 inhibitors in recent years, and three MCL-1 selective inhibitors have advanced to clinical trials. This review briefly discusses recent advances in the develop ...[more]

PMID: 30425521

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