Ontology highlight
ABSTRACT:
SUBMITTER: Chowdhury A
PROVIDER: S-EPMC6205837 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Chowdhury Arpita A Aich Abhishek A Jain Gaurav G Wozny Katharina K Lüchtenborg Christian C Hartmann Magnus M Bernhard Olaf O Balleiniger Martina M Alfar Ezzaldin Ahmed EA Zieseniss Anke A Toischer Karl K Guan Kaomei K Rizzoli Silvio O SO Brügger Britta B Fischer Andrè A Katschinski Dörthe M DM Rehling Peter P Dudek Jan J
Cell reports 20181001 3
Mitochondria fulfill vital metabolic functions and act as crucial cellular signaling hubs, integrating their metabolic status into the cellular context. Here, we show that defective cardiolipin remodeling, upon loss of the cardiolipin acyl transferase tafazzin, decreases HIF-1α signaling in hypoxia. Tafazzin deficiency does not affect posttranslational HIF-1α regulation but rather HIF-1α gene expression, a dysfunction recapitulated in iPSC-derived cardiomyocytes from Barth syndrome patients with ...[more]