Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner.

ABSTRACT:

Background

Antiangiogenic agents are commonly used in lung and colon cancer treatments, however, rapid development of drug resistance limits their efficacy.

Methods

Lentinan (LNT) is a biologically active compound extracted from Lentinus edodes. The effects of LNT on tumor angiogenesis were evaluated by immunohistochemistry in murine LAP0297 lung and CT26 colorectal tumor models. The impacts of LNT on immune cells and gene expression in tumor tissues were determined by flow cytometry, qPCR, and ELISA. Nude mice and IFNγ blockade were used to investigate the mechanism of LNT affecting on tumor angiogenesis. The data sets were compared using two-tailed student's t tests or ANOVA.

Results

We found that LNT inhibited tumor angiogenesis and the growth of lung and colon can

SUBMITTER: Deng S 

PROVIDER: S-EPMC6206909 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature