The anticancer mechanism investigation of Tanshinone II_A by pharmacological clustering in protein network.

ABSTRACT:

Background

Cancer is the second most common cause of death globally. The anticancer effects of Tanshinone II_A (Tan II_A) has been confirmed by numerous researches. However, the underlying mechanism remained to be integrated in systematic format. Systems biology embraced the complexity of cancer; therefore, a system study approach was proposed in the present study to explore the anticancer mechanism of Tan II_A based on network pharmacology.

Method

Agilent Literature Search (ALS), a text-mining tool, was used to pull protein targets of Tan II_A. Then, pharmacological clustering was applied to classify obtained hits, the anticancer module was analysed further. The top ten essential nodes in the anticancer module were obtained by Cluster

SUBMITTER: Cao YF 

PROVIDER: S-EPMC6206912 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature