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Nodular gastritis in association with gastric cancer development before and after Helicobacter pylori eradication.


ABSTRACT: Background and Aim:Nodular gastritis is caused by Helicobacter pylori infection and is associated with the development of diffuse-type gastric cancer. This study examined the clinical characteristics of patients with nodular gastritis, including cancer incidence before and after H. pylori eradication. Methods:This was a retrospective study of patients who underwent upper endoscopy and were positive for H. pylori infection. We examined the clinical findings and follow-up data after H. pylori eradication in patients with and without nodular gastritis. Results:Of the 674 patients with H. pylori infections, nodular gastritis was observed in 114 (17%). It was more prevalent in women (69%) and young adults. Among patients with nodular gastritis, six (5%) had gastric cancer, all of which were of the diffuse type. Among the 19 (4%) patients with gastric cancer and no nodular gastritis, 16 had intestinal-type cancer. White spot aggregates in the corpus, a specific finding in patients with nodular gastritis, were more frequently observed in patients with gastric cancer than in those without (83% vs 26%, P?=?0.0025). Of 82 patients with nodular gastritis who had H. pylori eradicated successfully, none developed gastric cancer over a 3-year follow-up period, while 7 (3%) of 220 patients without nodular gastritis developed gastric cancer after H. pylori eradication. Conclusions:In patients with nodular gastritis, white spot aggregates in the corpus may indicate a higher risk of developing diffuse-type gastric cancer. Nodular gastritis may be an indication for eradication therapy to reduce the risk of cancer development after H. pylori eradication.

SUBMITTER: Nishikawa I 

PROVIDER: S-EPMC6207053 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Nodular gastritis in association with gastric cancer development before and after <i>Helicobacter pylori</i> eradication.

Nishikawa Izumi I   Kato Jun J   Terasoma Satoshi S   Matsutani Hiroyoshi H   Tamaki Hidehiko H   Tamaki Tetsuya T   Kuwashima Fumiaki F   Nakata Hiroya H   Tomeki Tatsuji T   Matsunaka Hideyuki H   Ibata Yumiko Y   Yamashita Yasunobu Y   Maekita Takao T   Higashi Katsuhiko K   Ichinose Masao M  

JGH open : an open access journal of gastroenterology and hepatology 20180325 3


<h4>Background and aim</h4>Nodular gastritis is caused by <i>Helicobacter pylori</i> infection and is associated with the development of diffuse-type gastric cancer. This study examined the clinical characteristics of patients with nodular gastritis, including cancer incidence before and after H. pylori eradication.<h4>Methods</h4>This was a retrospective study of patients who underwent upper endoscopy and were positive for H. pylori infection. We examined the clinical findings and follow-up dat  ...[more]

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