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The likelihood of improving physical activity after pulmonary rehabilitation is increased in patients with COPD who have better exercise tolerance.


ABSTRACT: Purpose:Pulmonary rehabilitation (PR) enhances exercise tolerance in patients with COPD; however, improvements in physical activity (PA) are not guaranteed. This study explored the relationship between baseline exercise tolerance and changes in PA after PR. Materials and methods:Patient data from prospective clinical trials in the PR settings of Athens and Leuven (2008-2016) were analyzed. Validated PA monitors were worn for 1 week before and after a 12-week program. The proportion of patients who improved PA levels ?1,000 steps/day ("PA responders") after PR was compared between those with initial 6-minute walk distance [6MWDi] <350 m and ?350 m. Baseline predictors of PA change were evaluated via univariate and multivariate logistic regression analyses. Results:Two hundred thirty-six patients with COPD (median [IQR] FEV1 44 [33-59] % predicted, age 65±8 years, 6MWDi 416 [332-486] m) were included. The proportion of "PA responders" after PR was significantly greater in those with higher vs lower 6MWDi (37.9% vs 16.4%, respectively; P<0.001). 6MWDi group classification was the strongest baseline independent predictor of PA improvement (univariate OR 3.10, 95% CI 1.51-6.36). Conclusion:The likelihood of improving PA after PR is increased with greater 6MWDi. Baseline exercise tolerance appears as an important stratification metric for future research in this field.

SUBMITTER: Osadnik CR 

PROVIDER: S-EPMC6207410 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The likelihood of improving physical activity after pulmonary rehabilitation is increased in patients with COPD who have better exercise tolerance.

Osadnik Christian R CR   Loeckx Matthias M   Louvaris Zafeiris Z   Demeyer Heleen H   Langer Daniel D   Rodrigues Fernanda M FM   Janssens Wim W   Vogiatzis Ioannis I   Troosters Thierry T  

International journal of chronic obstructive pulmonary disease 20181024


<h4>Purpose</h4>Pulmonary rehabilitation (PR) enhances exercise tolerance in patients with COPD; however, improvements in physical activity (PA) are not guaranteed. This study explored the relationship between baseline exercise tolerance and changes in PA after PR.<h4>Materials and methods</h4>Patient data from prospective clinical trials in the PR settings of Athens and Leuven (2008-2016) were analyzed. Validated PA monitors were worn for 1 week before and after a 12-week program. The proportio  ...[more]

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