Patterns of schizophrenia symptoms: hidden structure in the PANSS questionnaire.
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ABSTRACT:
SUBMITTER: Lefort-Besnard J
PROVIDER: S-EPMC6207565 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Patterns of schizophrenia symptoms: hidden structure in the PANSS questionnaire.
Lefort-Besnard Jérémy J Varoquaux Gaël G Derntl Birgit B Gruber Oliver O Aleman Andre A Jardri Renaud R Sommer Iris I Thirion Bertrand B Bzdok Danilo D
Translational psychiatry 20181030 1
The clinical presentation of patients with schizophrenia has long been described to be very heterogeneous. Coherent symptom profiles can probably be directly derived from behavioral manifestations quantified in medical questionnaires. The combination of machine learning algorithms and an international multi-site dataset (n = 218 patients) identified distinctive patterns underlying schizophrenia from the widespread PANSS questionnaire. Our clustering approach revealed a negative symptom patient g ...[more]
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