Ontology highlight
ABSTRACT:
SUBMITTER: Lv B
PROVIDER: S-EPMC6207613 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lv Bo B Cheng Xiyuan X Sharp Frank R FR Ander Bradley P BP Liu Da Zhi DZ
Frontiers in neuroscience 20181024
<b>Aim:</b> Our previous study demonstrated miR-122 mimic decreased NOS2 expression in blood leucocytes and improved stroke outcomes when given immediately after middle cerebral artery occlusion (MCAO) in rats. Since NOS2 is associated with neuro-inflammation in stroke and decreasing NOS2 expression alone in leucocytes is insufficient to improve stroke outcomes, we hypothesized that miR-122 mimic may also decrease NOS2 expression in brain microvascular endothelial cells (BMVECs) even at extended ...[more]