Ontology highlight
ABSTRACT:
SUBMITTER: Friedrich T
PROVIDER: S-EPMC6207695 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Friedrich Thomas T Ilicic Katarina K Greubel Christoph C Girst Stefanie S Reindl Judith J Sammer Matthias M Schwarz Benjamin B Siebenwirth Christian C Walsh Dietrich W M DWM Schmid Thomas E TE Scholz Michael M Dollinger Günther G
Scientific reports 20181030 1
DNA double strand breaks (DSB) play a pivotal role for cellular damage, which is a hazard encountered in toxicology and radiation protection, but also exploited e.g. in eradicating tumors in radiation therapy. It is still debated whether and in how far clustering of such DNA lesions leads to an enhanced severity of induced damage. Here we investigate - using focused spots of ionizing radiation as damaging agent - the spatial extension of DNA lesion patterns causing cell inactivation. We find tha ...[more]