Ontology highlight
ABSTRACT:
SUBMITTER: Kumawat AK
PROVIDER: S-EPMC6207937 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kumawat Ashok K AK Yu Chen C Mann Elizabeth A EA Schridde Anika A Finnemann Silvia C SC Mowat Allan McI AM
European journal of immunology 20180508 7
Macrophages play a crucial role in maintaining homeostasis in the intestine, but the underlying mechanisms have not yet been elucidated fully. Here, we show for the first time that mature intestinal macrophages in mouse intestine express high levels of αvβ5 integrin, which acts as a receptor for the uptake of apoptotic cells and can activate molecules involved in several aspects of tissue homeostasis such as angiogenesis and remodeling of the ECM. αvβ5 is not expressed by other immune cells in t ...[more]