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A rare case report of heavy dose colchicine induced acute kidney injury.

ABSTRACT:

Background

Colchicine is a natural alkaloid that is mainly used for the treatment of inflammatory diseases. Effective and toxic doses are very similar, but case reports of higher colchicine doses inducing acute toxicosis is rare.

Case presentation

A 19-year-old woman was sent to the emergency room for taking 80 colchicine tablets (0.5 mg per tablet) 44 h previously. The main physical symptom was abdominal pain. Following ingestion, the patient suffered multi-system failure including renal, respiratory, circulatory, and digestive. Continuous renal replacement therapy (CRRT) and other treatment measures were used to remove metabolic wastes and poisons, and to treat other complications. Renal function was restored after a series of treatments.

Conclusion

We report a case of an acute kidney injury induced by an overdose of colchicine. CRRT and a series of related treatments were beneficial for the treatment of colchicine poisoning.

SUBMITTER: Zhong H

PROVIDER: S-EPMC6208074 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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A rare case report of heavy dose colchicine induced acute kidney injury.

Zhong Hongzhen H Zhong Zhiqing Z Li Hongyan H Zhou Tianbiao T Xie Weiji W

BMC pharmacology & toxicology 20181030 1

<h4>Background</h4>Colchicine is a natural alkaloid that is mainly used for the treatment of inflammatory diseases. Effective and toxic doses are very similar, but case reports of higher colchicine doses inducing acute toxicosis is rare.<h4>Case presentation</h4>A 19-year-old woman was sent to the emergency room for taking 80 colchicine tablets (0.5 mg per tablet) 44 h previously. The main physical symptom was abdominal pain. Following ingestion, the patient suffered multi-system failure includi ...[more]

PMID: 30376897

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