Murine Oviductosomes (OVS) microRNA profiling during the estrous cycle: Delivery of OVS-borne microRNAs to sperm where miR-34c-5p localizes at the centrosome.
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ABSTRACT:
SUBMITTER: Fereshteh Z
PROVIDER: S-EPMC6208369 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Murine Oviductosomes (OVS) microRNA profiling during the estrous cycle: Delivery of OVS-borne microRNAs to sperm where miR-34c-5p localizes at the centrosome.
Fereshteh Zeinab Z Schmidt Skye A SA Al-Dossary Amal A AA Accerbi Monica M Arighi Cecilia C Cowart Julie J Song Jia L JL Green Pamela J PJ Choi Kyungmin K Yoo Soonmoon S Martin-DeLeon Patricia A PA
Scientific reports 20181031 1
Oviductosomes (OVS) are nano-sized extracellular vesicles secreted in the oviductal luminal fluid by oviductal epithelial cells and known to be involved in sperm capacitation and fertility. Although they have been shown to transfer encapsulated proteins to sperm, cargo constituents other than proteins have not been identified. Using next-generation sequencing, we demonstrate that OVS are carriers of microRNAs (miRNAs), with 272 detected throughout the estrous cycle. Of the 50 most abundant, 6 (1 ...[more]
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