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Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study.


ABSTRACT: Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This study developed an age-stratified susceptible-exposed-infectious-recovered model using a recently published contact matrix to depict measles transmissions between individuals in seven age groups. Hubei, a high measles-incidence province in central China, was the selected setting. The baseline scenario was calibrated by fitting with the 2012-2015 age-stratified incidence data. SIAs targeting multiple age groups were simulated. Adult-targeted (>29 years) two-year SIA cycles produced the greatest annual incidence rate decrease, reducing incidences by half over a long timespan with 90% coverage levels. Incidences could remain below 10/100,000 until 2030 if SIAs were provided to individuals ?6 years old with at least 50% coverage. These findings will help officials prioritize supplementary vaccination strategies. Public health officials in China should consider adult-to-adult transmissions and provide adult-targeted SIAs. Although officials have reported approximately 90% SIA coverage in the past, SIAs for the adult population should be provided on shorter intervals, particularly for the aging population with decreased immunity.

SUBMITTER: Chong KC 

PROVIDER: S-EPMC6208397 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study.

Chong Ka Chun KC   Zhang Chi C   Jia Katherine Min KM   Zee Benny Chung Ying BCY   Luo Tongyong T   Wang Lei L   Tam Greta Chun Huen GCH   Sun Riyang R   Wang Maggie Haitian MH   Guan Xuhua X  

Scientific reports 20181031 1


Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This study developed an age-stratified susceptible-exposed-infectious-recovered model using a recently published contact matrix to depict measles transmissions between individuals in seven  ...[more]

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