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Impact of primary breast cancer therapy on energetic capacity and body composition.


ABSTRACT: PURPOSE:This observational study was designed to measure baseline energy parameters and body composition in early-stage breast cancer patients, and to follow changes during and after various modalities of treatment. This will provide information to aid in the development of individualized physical activity intervention strategies. METHODS:Patients with newly diagnosed stage 0-III breast cancer were enrolled into three cohorts: A (local therapy alone), B (endocrine therapy), or C (chemotherapy with or without endocrine therapy). At baseline, 6 months, and 12 months, subjects underwent a stationary bicycle protocol to assess power generation and DEXA to assess body composition. RESULTS:Eighty-three patients enrolled. Patients had low and variable levels of power generation at baseline (mean power per kilogram lean mass 1.55 W/kg, SD 0.88). Power normalized to lean body mass (W/kg) decreased significantly, and similarly, by 6 months in cohorts B (1.42-1.04 W/kg, p?=?0.008) and C (1.53-1.18 W/kg, p?

SUBMITTER: Ballinger TJ 

PROVIDER: S-EPMC6208924 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Impact of primary breast cancer therapy on energetic capacity and body composition.

Ballinger Tarah J TJ   Reddy Anurag A   Althouse Sandra K SK   Nelson Emily M EM   Miller Kathy D KD   Sledge Jeffrey S JS  

Breast cancer research and treatment 20180822 2


<h4>Purpose</h4>This observational study was designed to measure baseline energy parameters and body composition in early-stage breast cancer patients, and to follow changes during and after various modalities of treatment. This will provide information to aid in the development of individualized physical activity intervention strategies.<h4>Methods</h4>Patients with newly diagnosed stage 0-III breast cancer were enrolled into three cohorts: A (local therapy alone), B (endocrine therapy), or C (  ...[more]

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