Ontology highlight
ABSTRACT:
SUBMITTER: Wakatsuki T
PROVIDER: S-EPMC6209002 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wakatsuki Takeru T Yamamoto Noriko N Sano Takeshi T Chin Keisho K Kawachi Hiroshi H Takahari Daisuke D Ogura Mariko M Ichimura Takashi T Nakayama Izuma I Osumi Hiroki H Matsushima Tomohiro T Suenaga Mitsukuni M Shinozaki Eiji E Hiki Naoki N Ishikawa Yuichi Y Yamaguchi Kensei K
Journal of gastroenterology 20180409 11
<h4>Background</h4>There is growing interest in the clinical significance of intratumoral HER2 heterogeneity. Its prognostic and predictive impacts on trastuzumab efficacy were demonstrated in breast cancer. However, its clinical significance in gastric cancer is still unclear.<h4>Methods</h4>Twenty-eight HER2-positive gastric cancer patients who had gastrectomy prior to trastuzumab-based chemotherapy were consecutively enrolled. Intratumoral HER heterogeneity was evaluated using whole-tissue se ...[more]