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Robust Findings From 25 Years of PTSD Genetics Research.

ABSTRACT: PURPOSE OF REVIEW:The purpose of this review is to contextualize findings from the first 25 years of PTSD genetics research, focusing on the most robust findings and interpreting results in light of principles that have emerged from modern genetics studies. RECENT FINDINGS:Genome-wide association studies (GWAS) encompassing tens of thousands of participants enabled the first molecular genetic heritability and genetic correlation estimates for PTSD in 2017. In 2018, highly promising loci for PTSD were reported, including variants in and near the CAMKV, KANSL1, and TCF4 genes. Twin studies from 25 years ago established that PTSD is genetically influenced and foreshadowed the molecular genetic findings of today. Discoveries that were impossible with smaller studies have been achieved via collaborative/team-science efforts. Most promisingly, individual genomic loci offer entirely novel clues about PTSD etiology, providing the raw material for transformative discoveries, and the future of PTSD research is bright.

SUBMITTER: Duncan LE

PROVIDER: S-EPMC6209025 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Robust Findings From 25 Years of PTSD Genetics Research.

Duncan Laramie E LE Cooper Bryna N BN Shen Hanyang H

Current psychiatry reports 20181023 12

<h4>Purpose of review</h4>The purpose of this review is to contextualize findings from the first 25 years of PTSD genetics research, focusing on the most robust findings and interpreting results in light of principles that have emerged from modern genetics studies.<h4>Recent findings</h4>Genome-wide association studies (GWAS) encompassing tens of thousands of participants enabled the first molecular genetic heritability and genetic correlation estimates for PTSD in 2017. In 2018, highly promisin ...[more]

PMID: 30350223

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Project description:BackgroundGender mainstreaming has been central to the development agenda for advancing gender equality globally for nearly three decades. We examined key learning across gender mainstreaming models and experiences and assess key successes and challenges in actualising gender mainstreaming's transformative potential, in order to inform future research agendas.MethodsWe reviewed 27 years of peer-reviewed literature on gender mainstreaming (1995-2022) and described scholarly publishing trends on the topic based on a set of 528 articles and bibliographic data retrieved from the Scopus database and supplemental coding. The review provides a thematic synthesis of the extant literature, assessing the evidence base to identify gaps and opportunities for future research and collaboration with practitioners. We also contextualise recent research by tracing common threads of scholarly and practitioner discussions over the last two decades.ResultsPublications on gender mainstreaming have increased, primarily from authors with European and USA academic affiliations and funding. Gender mainstreaming in the health and law and policy sectors has been researched most frequently. Trends in co-authorship suggest increasing collaboration among academics, yet limited collaboration among researchers and practitioners. Widespread low citation counts raise concerns about engagement with the literature. Key challenges in gender mainstreaming identified include conceptual clarity, academic-practitioner disjunctures, politics, leadership and organisational culture, men's roles, intersectionality, monitoring and evaluation, and public health sectoral concerns.ConclusionsThe gender mainstreaming literature has expanded considerably over the last 25 years, yet there remain critical knowledge gaps, theoretical inconsistencies, weak research methods and evaluation processes, and implementation challenges. Funders, researchers, and practitioners have failed to prioritise bridging north-south and academic-practitioner divides in gender mainstreaming policy, programmes, and research. Integration of intersectionality also remains nascent. A more inclusive, collaborative, and structured research agenda on gender mainstreaming is needed to effect greater change in the face of persistent and new challenges. Engaging and empowering regional women's organisations, collaborative learning and research programmes, and joint research and advocacy groups; implementing gender-attuned editorial policies; and incorporating gender mainstreaming in educational curricula are recommended.

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Robust Findings From 25 Years of PTSD Genetics Research.

Publications

Robust Findings From 25 Years of PTSD Genetics Research.

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