Ontology highlight
ABSTRACT:
SUBMITTER: Wirnsberger G
PROVIDER: S-EPMC6209141 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wirnsberger Gerald G Zwolanek Florian F Asaoka Tomoko T Kozieradzki Ivona I Tortola Luigi L Wimmer Reiner A RA Kavirayani Anoop A Fresser Friedrich F Baier Gottfried G Langdon Wallace Y WY Ikeda Fumiyo F Kuchler Karl K Penninger Josef M JM
Nature medicine 20160718 8
Fungal infections claim an estimated 1.5 million lives each year. Mechanisms that protect from fungal infections are still elusive. Recognition of fungal pathogens relies on C-type lectin receptors (CLRs) and their downstream signaling kinase SYK. Here we report that the E3 ubiquitin ligase CBLB controls proximal CLR signaling in macrophages and dendritic cells. We show that CBLB associates with SYK and ubiquitinates SYK, dectin-1, and dectin-2 after fungal recognition. Functionally, CBLB defici ...[more]