Ontology highlight
ABSTRACT:
SUBMITTER: Jordi J
PROVIDER: S-EPMC6209392 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Jordi Josua J Guggiana-Nilo Drago D Bolton Andrew D AD Prabha Srishti S Ballotti Kaitlyn K Herrera Kristian K Rennekamp Andrew J AJ Peterson Randall T RT Lutz Thomas A TA Engert Florian F
Science advances 20181031 10
How appetite is modulated by physiological, contextual, or pharmacological influence is still unclear. Specifically, the discovery of appetite modulators is compromised by the abundance of side effects that usually limit in vivo drug action. We set out to identify neuroactive drugs that trigger only their intended single behavioral change, which would provide great therapeutic advantages. To identify these ideal bioactive small molecules, we quantified the impact of more than 10,000 compounds on ...[more]