P53 Is Active in Human Amniotic Fluid Stem Cells.
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ABSTRACT:
SUBMITTER: Rodrigues M
PROVIDER: S-EPMC6209428 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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p53 Is Active in Human Amniotic Fluid Stem Cells.
Rodrigues Melissa M Antonucci Ivana I Elabd Seham S Kancherla Shilpa S Marchisio Marco M Blattner Christine C Stuppia Liborio L
Stem cells and development 20181002 21
Despite increasing interest in human amniotic fluid cells, very little is known about the regulation and function of p53 in this cell type. In this study, we show that undifferentiated human amniotic fluid cells express p53, yet at lower levels than in cancer cells. The p53 protein in amniotic fluid cells is mainly localized in the nuclei, however, its antiproliferative activity is compromised in these cells. Igf2, a maternal imprinted gene, and c-jun, a proto-oncogene, are regulated by p53 in t ...[more]
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