Ontology highlight
ABSTRACT:
SUBMITTER: Winckler B
PROVIDER: S-EPMC6209849 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Winckler Bettina B Faundez Victor V Maday Sandra S Cai Qian Q Guimas Almeida Cláudia C Zhang Huaye H
The Journal of neuroscience : the official journal of the Society for Neuroscience 20181001 44
How do neurons adapt their endolysosomal system to address the particular challenge of membrane transport across their elaborate cellular landscape and to maintain proteostasis for the lifetime of the organism? Here we review recent findings that address this central question. We discuss the cellular and molecular mechanisms of endolysosomal trafficking and the autophagy pathway in neurons, as well as their role in neuronal development and degeneration. These studies highlight the importance of ...[more]