Ontology highlight
ABSTRACT:
SUBMITTER: Graham C
PROVIDER: S-EPMC6210057 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Graham Charlotte C Jozwik Agnieszka A Pepper Andrea A Benjamin Reuben R
Cells 20181001 10
Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably B-acute lymphoblastic leukaemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL). However, there are limitations, including inability to manufacture CAR-T cells from the patient's own T cells, disease progression and death prior to return of engineered cells. T cell dysfunction is known to occur in cancer patients, and several ...[more]