Ontology highlight
ABSTRACT:
SUBMITTER: Buchroithner J
PROVIDER: S-EPMC6210090 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Buchroithner Johanna J Erhart Friedrich F Pichler Josef J Widhalm Georg G Preusser Matthias M Stockhammer Günther G Nowosielski Martha M Iglseder Sarah S Freyschlag Christian F CF Oberndorfer Stefan S Bordihn Karin K von Campe Gord G Hoffermann Markus M Ruckser Reinhard R Rössler Karl K Spiegl-Kreinecker Sabine S Fischer Michael B MB Czech Thomas T Visus Carmen C Krumpl Günther G Felzmann Thomas T Marosi Christine C
Cancers 20181005 10
Dendritic cells (DCs) are antigen-presenting cells that are capable of priming anti-tumor immune responses, thus serving as attractive tools to generate tumor vaccines. In this multicentric randomized open-label phase II study, we investigated the efficacy of vaccination with tumor lysate-charged autologous DCs (Audencel) in newly diagnosed glioblastoma multiforme (GBM). Patients aged 18 to 70 years with histologically proven primary GBM and resection of at least 70% were randomized 1:1 to stand ...[more]