Ontology highlight
ABSTRACT:
SUBMITTER: Kaushik V
PROVIDER: S-EPMC6211070 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kaushik Vivek V Yakisich Juan Sebastian JS Kumar Anil A Azad Neelam N Iyer Anand K V AKV
Cancers 20180927 10
Ion homeostasis is extremely important for the survival of both normal as well as neoplastic cells. The altered ion homeostasis found in cancer cells prompted the investigation of several ionophores as potential anticancer agents. Few ionophores, such as Salinomycin, Nigericin and Obatoclax, have demonstrated potent anticancer activities against cancer stem-like cells that are considered highly resistant to chemotherapy and responsible for tumor relapse. The preclinical success of these compound ...[more]