Targeting the MAPK Pathway in RAS Mutant Cancers.
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ABSTRACT:
SUBMITTER: Hymowitz SG
PROVIDER: S-EPMC6211377 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Targeting the MAPK Pathway in RAS Mutant Cancers.
Hymowitz Sarah G SG Malek Shiva S
Cold Spring Harbor perspectives in medicine 20181101 11
Despite decades of extensive drug discovery efforts, there are currently no targeted therapies approved to treat KRAS mutant cancers. In this review, we highlight the challenges and opportunities in targeting KRAS mutant tumors through inhibition of mitogen-activated protein kinase (MAPK) signaling with conformation-specific kinase inhibitors. Through structural analysis and mechanistic studies with BRAF and mitogen-activated protein kinase (MEK) inhibitors, we describe how kinase-dependent and ...[more]
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