Dataset Information

Effects of feeding naturally contaminated deoxynivalenol diets to sows during late gestation and lactation in a high-yield specific pathogen-free herd.

ABSTRACT:

Background

The most prevalent Fusarium mycotoxin in grains is deoxynivalenol (DON). Contamination of swine feed with DON can result in reduced consumption and poor growth performance. Gestating and lactating sows need sufficient feed intake for fetus development during late gestation and milk production and body maintenance during lactation. Therefore, there is considerable concern in modern piglet production about the effects of DON contamination in sow feed. Most previous studies in sows have been done under experimental conditions, with DON levels ?2.8 mg/kg feed. The aim of the current field trial was to investigate the effects of feeding grains that are naturally contaminated with more realistic levels of DON on sows during late gestation and lactation.

Methods

In a commercial, high-yield specific pathogen-free piglet production unit, 45 Norwegian Landrace × Yorkshire sows were fed three diets from 93?±?1 days of gestation until weaning of the piglets, and average daily feed intake (ADFI), body weight (BW), production and reproduction performance, as well as sow blood parameters were recorded. Diets were made from naturally contaminated oats, with three concentration levels: 1) control (DON ResultsSows that were fed DON level 1 and 2 diets showed a 4-10% reduction in feed consumption during lactation, compared with sows in the control group. However, the DON-contaminated diets did not significantly affect sow BW or backfat thickness. Similarly, there were neither effects on production or reproduction performance, nor on blood parameters in the sows. The effects on skin temperature were variable.

Conclusion

Naturally contaminated diets with realistic, moderately increased DON levels, fed during late gestation and lactation in a modern high-yield piglet production farm, had limited effects on sow health and production.

SUBMITTER: Sayyari A

PROVIDER: S-EPMC6211461 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Effects of feeding naturally contaminated deoxynivalenol diets to sows during late gestation and lactation in a high-yield specific pathogen-free herd.

Sayyari Amin A Framstad Tore T Krogenæs Anette Kristine AK Sivertsen Tore T

Porcine health management 20181101

<h4>Background</h4>The most prevalent <i>Fusarium</i> mycotoxin in grains is deoxynivalenol (DON). Contamination of swine feed with DON can result in reduced consumption and poor growth performance. Gestating and lactating sows need sufficient feed intake for fetus development during late gestation and milk production and body maintenance during lactation. Therefore, there is considerable concern in modern piglet production about the effects of DON contamination in sow feed. Most previous studie ...[more]

PMID: 30410782

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Project description:BACKGROUND:Establishment of a beneficial microbiota profile for piglets as early in life as possible is important as it will impact their future health. In the current study, we hypothesized that resistant starch (RS) provided in the maternal diet during gestation and lactation will be fermented in their hindgut, which would favourably modify their milk and/or gut microbiota composition and that it would in turn affect piglets' microbiota profile and their absorptive and immune abilities. METHODS:In this experiment, 33% of pea starch was used in the diet of gestating and lactating sows and compared to control sows. Their faecal microbiota and milk composition were determined and the colonic microbiota, short-chain fatty acids (SCFA) production and gut health related parameters of the piglets were measured two days before weaning. In addition, their overall performances and post-weaning faecal score were also assessed. RESULTS:The RS diet modulated the faecal microbiota of the sows during gestation, increasing the Firmicutes:Bacteroidetes ratio and the relative abundance of beneficial genera like Bifidobacterium but these differences disappeared during lactation and maternal diets did not impact the colonic microbiota of their progeny. Milk protein concentration decreased with RS diet and lactose concentration increased within the first weeks of lactation while decreased the week before weaning with the RS diet. No effect of the dietary treatment, on piglets' bodyweight or diarrhoea frequency post-weaning was observed. Moreover, the intestinal morphology measured as villus height and crypt depths, and the inflammatory cytokines in the intestine of the piglets were not differentially expressed between maternal treatments. Only zonula occludens 1 (ZO-1) was more expressed in the ileum of piglets born from RS sows, suggesting a better closure of the mucosa tight junctions. CONCLUSION:Changes in the microbiota transferred from mother to piglets due to the inclusion of RS in the maternal diet are rather limited even though milk composition was affected.

Project description:In this study, the effects of maternal energy sources during late gestation and lactation on the performance, glucolipid metabolism, and oxidative status of sows and their offspring were investigated using a total of 75 (2 to 6 of parity) Landrace × Large White sows at day 85 of gestation under 3 different dietary treatments: SO diet (basal diet plus 3.0% and 5.0% soybean oil during late gestation and lactation, respectively), FO diet (basal diet plus 3.0%/5.0% fish oil during late gestation and lactation, respectively), and CS diet (basal diet plus 32%/42% corn starch during late gestation and lactation, respectively). All the 3 groups showed no obvious differences (P > 0.05) in the number of total piglets born, born alive, after cross-fostering, and at weaning, whereas the CS group exhibited a shorter farrowing duration (P < 0.05) and lower stillbirth rate (P < 0.05) when compared with the SO group. In addition, litter weight at birth was significantly higher in the CS group than in the SO or FO group (P < 0.05). Despite no notable differences in the ADG of suckling piglets among dietary treatments (P > 0.05), the CS group had greater feed intake than the SO group during the lactation period (P < 0.05). In neonatal piglets with normal birth weight (NBW, 1.3 to 1.5 kg), the CS group was lower than the SO group in the content of liver glycogen (P < 0.05) and the mRNA abundances of fatty acid synthase, acetyl-CoA carboxylase, fatty acid-binding protein 1, and acyl-CoA oxidase (P < 0.05). Interestingly, compared with the SO group, the FO group had a lower preweaning mortality rate (P < 0.05), but greater liver glycogen pools (P < 0.05) in neonatal piglets with low birth weight (LBW, <1.1 kg). Compared with the CS group, the FO group showed an increase in the plasma malondialdehyde levels (P < 0.05) of sows, as well as an increase of 8-hydroxy-deoxyguanosine (P < 0.05) and a decrease of ferric reducing ability of plasma (P < 0.05) in NBW piglets. Overall, the diet rich in starch decreased the stillbirth rate and increased the litter weight of neonatal piglets, the dietary supplementation with fish oil decreased preweaning mortality rate, and the diet with a low n6:n3 ratio increased the oxidative status of sows and their offspring.

Project description:BACKGROUND:The environmental impact of pig farming need to be reduced, with phosphorus (P) being of particular interest. Specified dietary regimens and management systems contribute to meet environmental concerns and reduce economic constrains. However, pregnant and lactating sows represent vulnerable individuals, whose reproductive potential and metabolic health status relies on adequate supply of macro- and micronutrients. The aim of this study was to investigate, whether sows fed with a dietary P content that is below or above current recommendations are capable to maintain mineral homeostasis during the reproduction cycle and which endogenous mechanisms are retrieved therefore in kidney and jejunum. Nulliparous gilts were fed iso-energetic diets with recommended (M), reduced (L), or high (H) amounts of mineral P supplements throughout gestation and lactation periods. Blood metabolites and hormones referring to the P homeostasis were retrieved prior to term (110?days of gestation) and at weaning (28?days of lactation). Transcriptional responses in kidney cortex and jejunal mucosa were analyzed using RNA sequencing. RESULTS:The variable dietary P content neither led to an aberration on fertility traits such as total weaned piglets nor to an effect on the weight pattern throughout gestation and lactation. Serum parameters revealed a maintained P homeostasis as reflected by unaltered inorganic P and calcium levels in L and H fed groups. The serum calcitriol levels were increased in lactating L sows. The endocrine responses to the dietary challenge were reflected at the transcriptional level. L diets led to an increase in CYP27B1 expression in the kidney compared to the H group and to an altered gene expression associated with lipid metabolism in the kidney and immune response in the jejunum. CONCLUSIONS:Our results suggest that current P requirements for gestating and lactating sows are sufficient and over supplementation of mineral P is not required. Shifts in renal and jejunal expression patterns between L and H groups indicate an affected intermediate metabolism, which long-term relevance needs to be further clarified.

Dataset Information

Effects of feeding naturally contaminated deoxynivalenol diets to sows during late gestation and lactation in a high-yield specific pathogen-free herd.

Background

Methods

Conclusion

Publications

Effects of feeding naturally contaminated deoxynivalenol diets to sows during late gestation and lactation in a high-yield specific pathogen-free herd.

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