Ontology highlight
ABSTRACT:
SUBMITTER: Ablinger M
PROVIDER: S-EPMC6211505 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ablinger Michael M Felder Thomas K TK Wimmer Monika M Zauner Roland R Hofbauer Peter P Lettner Thomas T Wolkersdorfer Martin M Lagler Florian B FB Diem Anja A Bauer Johann W JW Wally Verena V
Orphanet journal of rare diseases 20181101 1
Generalized severe epidermolysis bullosa simplex (EBS-gen sev) is caused by mutations within either the KRT5 or KRT14 gene, phenotypically resulting in blistering and wounding of the skin and mucous membranes after minor mechanical friction. In a clinical phase 2/3 trial, diacerein has recently been shown to significantly reduce blister numbers upon topical application. In this study we addressed basic pharmacokinetic parameters of locally applied diacerein in vitro and in vivo. Ex vivo experime ...[more]