Dataset Information

Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China.

ABSTRACT:

Background

Vitamin D could be a mediator in the association between tuberculosis (TB) and diabetes mellitus (DM). A large scale multi-center study confirmed that TB patients with DM had significantly lower serum vitamin D level compared with those without DM and reported that DM was a strong independent risk factor for vitamin D deficiency.

Objectives

This study was undertaken to determine amongst patients with both TB and DM living in different economically defined areas in China: i) their baseline characteristics, ii) their vitamin D status and iii) whether certain baseline characteristics were associated with vitamin D deficiency.

Methods

In DM-TB patients consecutively attending seven clinics or hospitals, we measured 25 hydroxycholecalciferol at the time of registration using electrochemiluminescence in a COBASE 601 Roche analyser by chemiluminescence immunoassay. Data analysis was performed using chi square test and multivariate logistic regression.

Results

There were 178 DM-TB patients that included 50 from economically well-developed areas, 103 from better-off areas and 25 from a poverty area. Median vitamin D levels in well-developed, better-off and poverty areas were 11.5ng/ml, 12.2ng/ml and 11.5ng/ml respectively. Amongst all patients, 149 (84%) had vitamin D deficiency-91 (51%) with vitamin D deficiency (10-19.9 ng/ml) and 58 (33%) with severe deficiency (< 10 ng/ml). There was a significantly higher proportion with vitamin D deficiency in the poverty area. The adjusted odds of vitamin D deficiency (25-(OH)D3 <20 ng/ml) were significantly higher in those with longer history of DM (P = 0.038) and with HbA1c?10% (P = 0.003).

Conclusion

Over 80% of TB patients with DM in China were vitamin D deficient, with risk factors being residence in a poverty area, a long duration of DM and uncontrolled DM. TB programme managers and clinicians need to pay more attention to the vitamin D status of their patients.

SUBMITTER: Zhao X

PROVIDER: S-EPMC6211694 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China.

Zhao Xin X Yuan Yanli Y Lin Yan Y Zhang Tiejuan T Bai Yunlong Y Kang Demei D Li Xianhui X Kang Wanli W Dlodlo Riitta A RA Harries Anthony D AD

PloS one 20181101 11

<h4>Background</h4>Vitamin D could be a mediator in the association between tuberculosis (TB) and diabetes mellitus (DM). A large scale multi-center study confirmed that TB patients with DM had significantly lower serum vitamin D level compared with those without DM and reported that DM was a strong independent risk factor for vitamin D deficiency.<h4>Objectives</h4>This study was undertaken to determine amongst patients with both TB and DM living in different economically defined areas in China ...[more]

PMID: 30383776

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Dataset Information

Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China.

Background

Objectives

Methods

Results

Conclusion

Publications

Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China.

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