Gene pair based prognostic signature for colorectal colon cancer.

ABSTRACT:

Background

The identification of high-risk colorectal cancer (CRC) patient is key to individualized treatment after surgery and reliable prognostic biomarkers are needed identifying high-risk CRC patients.

Methods

We developed a gene pair based prognostic signature that could can the prognosis risk in patients with CRC. This study retrospectively analyzed 4 public CRC datasets, and 1123 patients with CRC were divided into a training cohort (n = 300) and 3 independent validation cohorts (n = 507, 226, and 90 patients).

Results

A signature of 9 prognosis-related gene pairs (PRGPs) consisting of 17 unique genes was constructed. Then, a PRGP index (PRGPI) was constructed and divided patients into high- and low-risk groups according to the signature score. Patients in the

SUBMITTER: Shu P 

PROVIDER: S-EPMC6211904 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature