Gene pair based prognostic signature for colorectal colon cancer.

ABSTRACT: BACKGROUND:The identification of high-risk colorectal cancer (CRC) patient is key to individualized treatment after surgery and reliable prognostic biomarkers are needed identifying high-risk CRC patients. METHODS:We developed a gene pair based prognostic signature that could can the prognosis risk in patients with CRC. This study retrospectively analyzed 4 public CRC datasets, and 1123 patients with CRC were divided into a training cohort (n?=?300) and 3 independent validation cohorts (n?=?507, 226, and 90 patients). RESULTS:A signature of 9 prognosis-related gene pairs (PRGPs) consisting of 17 unique genes was constructed. Then, a PRGP index (PRGPI) was constructed and divided patients into high- and low-risk groups according to the signature score. Patients in the high-risk group showed a poorer relapse-free survival than the low-risk group in both the training cohort [hazard ratio (HR) range, 4.6, 95% confidence interval (95% CI), 2.55-8.32; P?

SUBMITTER: Shu P 

PROVIDER: S-EPMC6211904 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature