Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC6212334 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wang Miaoyi M Sun Yunxiang Y Cao Xueying X Peng Guotao G Javed Ibrahim I Kakinen Aleksandr A Davis Thomas P TP Lin Sijie S Liu Jingquan J Ding Feng F Ke Pu Chun PC
Nanoscale 20181101 42
The development of biocompatible nanomaterials has become a new frontier in the detection, treatment and prevention of human amyloid diseases. Here we demonstrated the use of graphene quantum dots (GQDs) as a potent inhibitor against the in vivo aggregation and toxicity of human islet amyloid polypeptide (IAPP), a hallmark of type 2 diabetes. GQDs initiated contact with IAPP through electrostatic and hydrophobic interactions as well as hydrogen bonding, which subsequently drove the peptide fibri ...[more]