Acute microglia ablation induces neurodegeneration in the somatosensory system.
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ABSTRACT:
SUBMITTER: Rubino SJ
PROVIDER: S-EPMC6212411 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Acute microglia ablation induces neurodegeneration in the somatosensory system.
Rubino Stephen J SJ Mayo Lior L Wimmer Isabella I Siedler Victoria V Brunner Florian F Hametner Simon S Madi Asaf A Lanser Amanda A Moreira Thais T Donnelly Dustin D Cox Laura L Rezende Rafael Machado RM Butovsky Oleg O Lassmann Hans H Weiner Howard L HL
Nature communications 20181101 1
Previous studies have reported that microglia depletion leads to impairment of synapse formation and these cells rapidly repopulate from CNS progenitors. However, the impact of microglia depletion and repopulation in the long-term state of the CNS environment has not been characterized. Here, we report that acute and synchronous microglia depletion and subsequent repopulation induces gray matter microgliosis, neuronal death in the somatosensory cortex and ataxia-like behavior. We find a type 1 i ...[more]
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