Ontology highlight
ABSTRACT:
SUBMITTER: Pant A
PROVIDER: S-EPMC6212536 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Pant A A Kumar R R Wani N A NA Verma S S Sharma R R Pande V V Saxena A K AK Dixit R R Rai R R Pandey K C KC
Scientific reports 20181101 1
Falcipains are major haemoglobinases of Plasmodium falciparum required for parasite growth and development. They consist of pro- and mature domains that interact via 'hot-spot' interactions and maintain the structural integrity of enzyme in zymogen state. Upon sensing the acidic environment, these interactions dissociate and active enzyme is released. For inhibiting falcipains, several active site inhibitors exist, however, compounds that target via allosteric mechanism remains uncharacterized. ...[more]