Ontology highlight
ABSTRACT:
SUBMITTER: Lincoln FA
PROVIDER: S-EPMC6212537 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lincoln Frank A FA Imig Dirke D Boccellato Chiara C Juric Viktorija V Noonan Janis J Kontermann Roland E RE Allgöwer Frank F Murphy Brona M BM Rehm Markus M
Cell death & disease 20181101 11
Due to the lack of effective treatments for glioblastoma (GBM), we here studied the responsiveness of GBM cell lines to the combination of death ligand, TRAIL and the IAP antagonist, TL32711 (Birinapant). Responses were highly heterogeneous, with synergistic apoptosis as well as treatment resistance observed. Caspase-8 and Bid, together with caspase-3, form a nonlinear signalling hub that efficiently induced apoptosis in responder cell lines. Cells resistant to TRAIL/TL32711 expressed low amount ...[more]