Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF.
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ABSTRACT:
SUBMITTER: Bortolus M
PROVIDER: S-EPMC6212873 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF.
Bortolus Marco M Costantini Paola P Doni Davide D Carbonera Donatella D
International journal of molecular sciences 20181011 10
Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two parts, synthesized in different pathways. The cubane sub-cluster requires the normal iron-sulfur cluster maturation machinery. The [2Fe] sub-cluster instead requires a dedicated set of maturase proteins, HydE, HydF, and HydG that work to assemble the cluster and deliver it to the apo-hydrogenase. In particular, the delivery is performed by ...[more]
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