Pleiotropic Effects of Metformin on Cancer.
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ABSTRACT:
SUBMITTER: Schulten HJ
PROVIDER: S-EPMC6213406 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Pleiotropic Effects of Metformin on Cancer.
International journal of molecular sciences 20180920 10
Metformin (MTF) is a natural compound derived from the legume <i>Galega officinalis</i>. It is the first line antidiabetic drug for type 2 diabetes (T2D) treatment. One of its main antidiabetic effects results from the reduction of hepatic glucose release. First scientific evidence for the anticancer effects of MTF was found in animal research, published in 2001, and some years later a retrospective observational study provided evidence that linked MTF to reduced cancer risk in T2D patients. Its ...[more]
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