Renal Injury during Long-Term Crizotinib Therapy.
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ABSTRACT:
SUBMITTER: Yasuma T
PROVIDER: S-EPMC6213486 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Renal Injury during Long-Term Crizotinib Therapy.
Yasuma Taro T Kobayashi Tetsu T D'Alessandro-Gabazza Corina N CN Fujimoto Hajime H Ito Kentaro K Nishii Yoichi Y Nishihama Kota K Baffour Tonto Prince P Takeshita Atsuro A Toda Masaaki M Gabazza Esteban C EC Taguchi Osamu O Yonemura Shigenori S Hataji Osamu O
International journal of molecular sciences 20180925 10
Crizotinib is highly effective against anaplastic lymphoma kinase-positive and c-ros oncogen1-positive non-small cell lung cancer. Renal dysfunction is associated with crizotinib therapy but the mechanism is unknown. Here, we report a case of anaplastic lymphoma kinase positive non-small cell lung cancer showing multiple cysts and dysfunction of the kidneys during crizotinib administration. We also present results demonstrating that long-term crizotinib treatment induces fibrosis and dysfunction ...[more]
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