Dataset Information

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum Venetum.

ABSTRACT: Four new meroterpenoids 1?4 and four new isocoumarinoids 5?8, along with five known isocoumarinoids (9?13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 1?5, 7, 9 and 10 showed weak ?-glucosidase inhibition with the IC50 values of 0.50, 0.66, 0.058, 0.20, 0.32, 0.036, 0.026 and 0.37 mM, respectively.

SUBMITTER: Xu Y

PROVIDER: S-EPMC6213923 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum Venetum.

Xu Yanchao Y Wang Cong C Liu Haishan H Zhu Guoliang G Fu Peng P Wang Liping L Zhu Weiming W

Marine drugs 20181001 10

Four new meroterpenoids 1⁻4 and four new isocoumarinoids 5⁻8, along with five known isocoumarinoids (9⁻13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with the salt-resistant medicinal plant, Apocynum venetum (Apocynaceae). Their structures were elucidated by means of spectroscopic analysis, X-ray crystallography, ECD spectra and quantum chemical calculations. Compounds 1⁻5, 7, 9 and ...[more]

PMID: 30275406

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Project description:BACKGROUND:Apocynum venetum L. is an important medicinal plant that is mainly distributed in the coastal areas and northwest of China. In addition to its high medical and economic value, its adaptation to saline-alkali and coastal saline lands makes A. venetum an ideal candidate for use in vegetation restoration. To date, the study of A. venetum has been limited in the northwest region of China, little attention has been paid to the genetic diversity and population structure of A. venetum populations in the coastal region. Here, we performed transcriptome sequencing of total RNA from A. venetum leaves and developed efficient expressed sequence tag-simple sequence repeat (EST-SSR) markers for analyzing the genetic diversity and population structure of A. venetum in the coastal region. RESULTS:A total of 86,890 unigenes were generated after de novo assembly, and 68,751 of which were successfully annotated by searching against seven protein databases. Furthermore, 14,072 EST-SSR loci were detected and 10,243 primer pairs were successfully designed from these loci. One hundred primer pairs were randomly selected and synthesized, twelve primer pairs were identified as highly polymorphic and further used for population genetic analysis. Population genetic analyses showed that A. venetum exhibited low level of genetic diversity (mean alleles per locus, NA?=?3.3; mean expected heterozygosity, HE?=?0.342) and moderate level of genetic differentiation among the populations (genetic differentiation index, FST?=?0.032-0.220) in the coastal region. Although the contemporary (mean mc?=?0.056) and historical (mean mh?=?0.106) migration rates among the six A. venetum populations were moderate, a decreasing trend over the last few generations was detected. Bayesian structure analysis clustered six populations into two major groups, and genetic bottlenecks were found to have occurred in two populations (QG, BH). CONCLUSIONS:Using novel EST-SSR markers, we evaluated the genetic variation of A. venetum in the coastal region and determined conservation priorities based on these findings. The large dataset of unigenes and SSRs identified in our study, combining samples from a broader range, will support further research on the conservation and evolution of this important coastal plant and its related species.

Dataset Information

Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum Venetum.

Publications

Meroterpenoids and Isocoumarinoids from a <i>Myrothecium</i> Fungus Associated with <i>Apocynum Venetum</i>.

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