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Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes.

ABSTRACT: Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates potent adaptive responses. Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines.

SUBMITTER: Sayour EJ

PROVIDER: S-EPMC6213933 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes.

Sayour Elias J EJ Mendez-Gomez Hector R HR Mitchell Duane A DA

International journal of molecular sciences 20180923 10

Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates pote ...[more]

PMID: 30249040

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