Ontology highlight
ABSTRACT:
SUBMITTER: Munoz-Bello JO
PROVIDER: S-EPMC6214013 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Muñoz-Bello J Omar JO Olmedo-Nieva Leslie L Castro-Muñoz Leonardo Josué LJ Manzo-Merino Joaquín J Contreras-Paredes Adriana A González-Espinosa Claudia C López-Saavedra Alejandro A Lizano Marcela M
International journal of molecular sciences 20181013 10
The Wnt/β-catenin signaling pathway regulates cell proliferation and differentiation and its aberrant activation in cervical cancer has been described. Persistent infection with high risk human papillomavirus (HR-HPV) is the most important factor for the development of this neoplasia, since E6 and E7 viral oncoproteins alter cellular processes, promoting cervical cancer development. A role of HPV-16 E6 in Wnt/β-catenin signaling has been proposed, although the participation of HPV-18 E6 has not ...[more]