Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC6214113 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Chen Geng G Xiong Lv L Wang Yumeng Y He Libo L Huang Rong R Liao Lanjie L Zhu Zuoyan Z Wang Yaping Y
International journal of molecular sciences 20181015 10
Integrin β-1 (ITGB1) is a transmembrane protein belonging to the integrin family and it plays an important role in viral entry. In this study, the <i>itgb1b</i> gene of the rare minnow, <i>Gobiocypris rarus</i>, was cloned and analyzed. To investigate the possible role of <i>itgb1b</i> on grass carp reovirus (GCRV) infection, we generated an ITGB1b-deficient rare minnow (ITGB1b<sup>-/-</sup>) using the CRISPR/Cas9 system. Following stimulation with GCRV, the survival time of the -ITGB1b<sup>-/-< ...[more]