Early detection and treatment strategies for breast cancer in low-income and upper middle-income countries: a modelling study.

ABSTRACT:

Background

Poor breast cancer survival in low-income and middle-income countries (LMICs) can be attributed to advanced-stage presentation and poor access to systemic therapy. We aimed to estimate the outcomes of different early detection strategies in combination with systemic chemotherapy and endocrine therapy in LMICs.

Methods

We adapted a microsimulation model to project outcomes of three early detection strategies alone or in combination with three systemic treatment programmes beyond standard of care (programme A): programme B was endocrine therapy for all oestrogen-receptor (ER)-positive cases; programme C was programme B plus chemotherapy for ER-negative cases; programme D was programme C plus chemotherapy for advanced ER-positive cases. The main outcomes were reducti

SUBMITTER: Birnbaum JK 

PROVIDER: S-EPMC6214657 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature