Ontology highlight
ABSTRACT:
SUBMITTER: Kamio Y
PROVIDER: S-EPMC6214667 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Kamio Yoshinobu Y Miyamoto Takeshi T Kimura Tetsuro T Mitsui Kazuha K Furukawa Hajime H Zhang Dingding D Yokosuka Kimihiko K Korai Masaaki M Kudo Daisuke D Lukas Ronald J RJ Lawton Michael T MT Hashimoto Tomoki T
Stroke 20181001 10
Background and Purpose- Tobacco cigarette smoking is considered to be a strong risk factor for intracranial aneurysmal rupture. Nicotine is a major biologically active constituent of tobacco products. Nicotine's interactions with vascular cell nicotinic acetylcholine receptors containing α7 subunits (α7*-nAChR) are thought to promote local inflammation and sustained angiogenesis. In this study, using a mouse intracranial aneurysm model, we assessed potential contributions of nicotine exposure an ...[more]