Immunotherapy of Primary Brain Tumors: Facts and Hopes.
Ontology highlight
ABSTRACT:
SUBMITTER: Buerki RA
PROVIDER: S-EPMC6214775 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Immunotherapy of Primary Brain Tumors: Facts and Hopes.
Buerki Robin A RA Chheda Zinal S ZS Okada Hideho H
Clinical cancer research : an official journal of the American Association for Cancer Research 20180605 21
The field of cancer immunotherapy has made exciting progress for some cancer types in recent years. However, recent failures of late-phase clinical trials evaluating checkpoint blockade in patients with glioblastoma (GBM) represent continued challenges for brain cancer immunotherapy. This is likely due to multiple factors including but not limited to marked genetic and antigenic heterogeneity, relatively low mutational loads, and paucity of GBM-infiltrating T cells. We review recent and ongoing ...[more]
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