Ontology highlight
ABSTRACT:
SUBMITTER: Hu D
PROVIDER: S-EPMC6214872 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Hu Dongli D Jablonowski Carolyn C Cheng Pei-Hsin PH AlTahan Alaa A Li Chunliang C Wang Yingdi Y Palmer Lance L Lan Cuixia C Sun Bingmei B Abu-Zaid Ahmed A Fan Yiping Y Brimble Mark M Gamboa Nicolas T NT Kumbhar Ramhari C RC Yanishevski David D Miller Kyle M KM Kang Guolian G Zambetti Gerard P GP Chen Taosheng T Yan Qin Q Davidoff Andrew M AM Yang Jun J
iScience 20181017
The p53 tumor suppressor pathway is frequently inactivated in human cancers. However, there are some cancer types without commonly recognized alterations in p53 signaling. Here we report that histone demethylase KDM5A is involved in the regulation of p53 activity. KDM5A is significantly amplified in multiple types of cancers, an event that tends to be mutually exclusive to p53 mutation. We show that KDM5A acts as a negative regulator of p53 signaling through inhibition of p53 translation via sup ...[more]